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KMID : 1036320210430010039
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Maxillofacial Plastic and Reconstructive Surgery
2021 Volume.43 No. 1 p.39 ~ p.39
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The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
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Lee In-Song
Chang Jun-Ho
Kim Dae-Won
Kim Seong-Gon
Kim Tae-Woo
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Abstract
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Background: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.
Method: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1?100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.
Results: In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1?100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).
Conclusion: 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
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KEYWORD
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4-hexylresorcinol, Sirtuin, NAD+
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